Application failed to initialize: 0x80070006
This problem normally happens when an operating system was upgraded to Windows Vista and running Windows Defender after that. This problem is triggered when you uninstall Windows Defender after upgrading your operating system to Windows Vista. If this applies to you, you need to restore Windows Vista using System Restore.
Restart your computer. Press F8 continuously before the Windows logo appears. In the Advanced Boot Options, use the arrow keys to navigate, select Safe Mode, and then hit Enter. Log in to the computer using your administrator account. Click Start, All Programs, Accessories, System Tools, and then click System Restore.
Follow the onscreen instructions to restore Windows Vista to an earlier restore point. If this method doesn’t fix your problem, you need to reinstall Windows Vista. If this is not a good idea, just use other antivirus programs to protect your computer such as Norton Internet Security, Norton AntiVirus, Kaspersky Internet Security, Panda Cloud Antivirus, and more.
To help you decide on the best antivirus to use, please visit my post Microsoft Security Essentials Failed Total Accuracy Test. There is still another possible solution with the help of the Windows registry. First, you need to create a backup of the current registry. Click Start, Run, and type without quotes “regedit” then hit Enter. In Registry Editor window, click File then select Export. See image.
In Export Registry File dialog box, browse to the folder where you want to save the backup file, type the name of the file, and then click Save. See image.
Once the backup has been created, open Notepad. Copy and paste the following texts in Notepad:
Windows Registry Editor Version 5.00
[HKEY_LOCAL_MACHINESYSTEMCurrentControlSetServicesWinDefend]
"DisplayName"="@%ProgramFiles%\Windows Defender\MsMpRes.dll,-103"
"ErrorControl"=dword:00000001
"Group"="COM Infrastructure"
"ImagePath"=hex(2):25,00,53,00,79,00,73,00,74,00,65,00,6d,00,52,00,6f,00,6f,00,
74,00,25,00,5c,00,53,00,79,00,73,00,74,00,65,00,6d,00,33,00,32,00,5c,00,73,
00,76,00,63,00,68,00,6f,00,73,00,74,00,2e,00,65,00,78,00,65,00,20,00,2d,00,
6b,00,20,00,73,00,65,00,63,00,73,00,76,00,63,00,73,00,00,00
"Start"=dword:00000002
"Type"=dword:00000020
"Description"="@%ProgramFiles%\Windows Defender\MsMpRes.dll,-3068"
"DependOnService"=hex(7):52,00,70,00,63,00,53,00,73,00,00,00,00,00
"ObjectName"="LocalSystem"
"ServiceSidType"=dword:00000001
"RequiredPrivileges"=hex(7):53,00,65,00,49,00,6d,00,70,00,65,00,72,00,73,00,6f,
00,6e,00,61,00,74,00,65,00,50,00,72,00,69,00,76,00,69,00,6c,00,65,00,67,00,
65,00,00,00,53,00,65,00,42,00,61,00,63,00,6b,00,75,00,70,00,50,00,72,00,69,
00,76,00,69,00,6c,00,65,00,67,00,65,00,00,00,53,00,65,00,52,00,65,00,73,00,
74,00,6f,00,72,00,65,00,50,00,72,00,69,00,76,00,69,00,6c,00,65,00,67,00,65,
00,00,00,53,00,65,00,44,00,65,00,62,00,75,00,67,00,50,00,72,00,69,00,76,00,
69,00,6c,00,65,00,67,00,65,00,00,00,53,00,65,00,43,00,68,00,61,00,6e,00,67,
00,65,00,4e,00,6f,00,74,00,69,00,66,00,79,00,50,00,72,00,69,00,76,00,69,00,
6c,00,65,00,67,00,65,00,00,00,53,00,65,00,53,00,65,00,63,00,75,00,72,00,69,
00,74,00,79,00,50,00,72,00,69,00,76,00,69,00,6c,00,65,00,67,00,65,00,00,00,
00,00
"FailureActions"=hex:80,51,01,00,00,00,00,00,00,00,00,00,03,00,00,00,14,00,00,
00,01,00,00,00,60,ea,00,00,01,00,00,00,60,ea,00,00,00,00,00,00,00,00,00,00
[HKEY_LOCAL_MACHINESYSTEMCurrentControlSetServicesWinDefendParameters]
"ServiceDllUnloadOnStop"=dword:00000001
"ServiceDll"=hex(2):25,00,50,00,72,00,6f,00,67,00,72,00,61,00,6d,00,46,00,69,
00,6c,00,65,00,73,00,25,00,5c,00,57,00,69,00,6e,00,64,00,6f,00,77,00,73,00,
20,00,44,00,65,00,66,00,65,00,6e,00,64,00,65,00,72,00,5c,00,6d,00,70,00,73,
00,76,00,63,00,2e,00,64,00,6c,00,6c,00,00,00
[HKEY_LOCAL_MACHINESYSTEMCurrentControlSetServicesWinDefendSecurity]
"Security"=hex:01,00,14,80,04,01,00,00,10,01,00,00,14,00,00,00,30,00,00,00,02,
00,1c,00,01,00,00,00,02,80,14,00,ff,01,0f,00,01,01,00,00,00,00,00,01,00,00,
00,00,02,00,d4,00,07,00,00,00,00,00,28,00,ff,01,0f,00,01,06,00,00,00,00,00,
05,50,00,00,00,b5,89,fb,38,19,84,c2,cb,5c,6c,23,6d,57,00,77,6e,c0,02,64,87,
00,0b,28,00,00,00,00,10,01,06,00,00,00,00,00,05,50,00,00,00,b5,89,fb,38,19,
84,c2,cb,5c,6c,23,6d,57,00,77,6e,c0,02,64,87,00,00,14,00,fd,01,02,00,01,01,
00,00,00,00,00,05,12,00,00,00,00,00,18,00,ff,01,0f,00,01,02,00,00,00,00,00,
05,20,00,00,00,20,02,00,00,00,00,14,00,9d,01,02,00,01,01,00,00,00,00,00,05,
04,00,00,00,00,00,14,00,8d,01,02,00,01,01,00,00,00,00,00,05,06,00,00,00,00,
00,28,00,15,00,00,00,01,06,00,00,00,00,00,05,50,00,00,00,49,59,9d,77,91,56,
e5,55,dc,f4,e2,0e,a7,8b,eb,ca,7b,42,13,56,01,01,00,00,00,00,00,05,12,00,00,
00,01,01,00,00,00,00,00,05,12,00,00,00
[HKEY_LOCAL_MACHINESYSTEMCurrentControlSetServicesWinDefendEnum]
"0"="Root\LEGACY_WINDEFEND\0000"
"Count"=dword:00000001
"NextInstance"=dword:00000001
Save the file and name it “newreg.reg” and close Notepad. Next, double-click on newreg.reg then select Yes when prompted by “Are you sure you want to add the information in the REG file to the registry”. Press OK on the confirmation and restart your computer. See if this fixes the problem. If this doesn’t fix it, find the backup file you created, double-click it then select Yes to merge it to the registry.