The file or directory is corrupted and unreadable in XP

Hi,
I am using Old version of Windows XP 32 bit and got this annoying error message when I tried to access a file from my directory. I could not understand the cause of this error. I need you help to fix this issue as soon as possible. Thanks in advance.

E:windowssystem32config is not accessible.
The file or directory is corrupted and unreadable.
