What to do when Anti-Virus acts nothing against virus?

I had a virus infection on my PC few days ago and it still is. I need to delete the virus before it would brick up my PC. The virus is located in a subfolder in D:. I came to know this when in opened a folder named NVIDIA but I don't have any GPU. My PC froze after that. When I tried a full system scan with Avast, it shows nothing but still the thing is in D:.
